Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial UPR

Mitochondrial genomes (mtDNA) encode essential oxidative phosphorylation (OxPhos) components. Because hundreds of mtDNAs exist per cell, the presence of a deletion in a single mtDNA has little impact. However, if the deletion genome is enriched, OxPhos declines resulting in cellular dysfunction. For...

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Detalles Bibliográficos
Autores principales: Lin, Yi-Fan, Schulz, Anna M., Pellegrino, Mark W., Lu, Yun, Shaham, Shai, Haynes, Cole M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873342/
https://www.ncbi.nlm.nih.gov/pubmed/27135930
http://dx.doi.org/10.1038/nature17989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873342/
https://www.ncbi.nlm.nih.gov/pubmed/27135930
http://dx.doi.org/10.1038/nature17989

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