Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene correction.(1,2) Although most genetic diseases arise from point mutations, current approaches to point mutation correction are inefficient and typically induce an abundance of r...

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Detalles Bibliográficos
Autores principales: Komor, Alexis C., Kim, Yongjoo B., Packer, Michael S., Zuris, John A., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873371/
https://www.ncbi.nlm.nih.gov/pubmed/27096365
http://dx.doi.org/10.1038/nature17946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873371/
https://www.ncbi.nlm.nih.gov/pubmed/27096365
http://dx.doi.org/10.1038/nature17946

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