Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

Mycobacterium tuberculosis (Mtb) survives within macrophages by evading delivery to the lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source of nutrients. Here we show that by inducing miR-33 and its passenger strand miR-33*, Mtb inhibits integrated pathways inv...

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Detalles Bibliográficos
Autores principales: Ouimet, Mireille, Koster, Stefan, Sakowski, Erik, Ramkhelawon, Bhama, van Solingen, Coen, Oldebeken, Scott, Karunakaran, Denuja, Celhay, Cynthia Portal, Sheedy, Frederick J., Ray, Tathagat Dutta, Cecchini, Katharine, Zamore, Philip D, Rayner, Katey J, Marcel, Yves L, Philips, Jennifer A, Moore, Kathryn J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873392/
https://www.ncbi.nlm.nih.gov/pubmed/27089382
http://dx.doi.org/10.1038/ni.3434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873392/
https://www.ncbi.nlm.nih.gov/pubmed/27089382
http://dx.doi.org/10.1038/ni.3434

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