New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis

Benzo(a)pyrene (BaP) is a ubiquitous carcinogen resulting from incomplete combustion of organic compounds and also present at high levels in cigarette smoke. A wide range of biological effects has been attributed to BaP and its genotoxic metabolite BPDE, but the contribution to BaP toxicity of inter...

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Detalles Bibliográficos
Autores principales: Souza, Terezinha, Jennen, Danyel, van Delft, Joost, van Herwijnen, Marcel, Kyrtoupolos, Soterios, Kleinjans, Jos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873527/
https://www.ncbi.nlm.nih.gov/pubmed/26238291
http://dx.doi.org/10.1007/s00204-015-1572-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873527/
https://www.ncbi.nlm.nih.gov/pubmed/26238291
http://dx.doi.org/10.1007/s00204-015-1572-z

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