Cargando…
Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which...
Autores principales: | van der Plas, Mariena J. A., Bhongir, Ravi K. V., Kjellström, Sven, Siller, Helena, Kasetty, Gopinath, Mörgelin, Matthias, Schmidtchen, Artur |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873665/ https://www.ncbi.nlm.nih.gov/pubmed/27181065 http://dx.doi.org/10.1038/ncomms11567 |
Ejemplares similares
-
Host Defense Peptides of Thrombin Modulate Inflammation and Coagulation in Endotoxin-Mediated Shock and Pseudomonas aeruginosa Sepsis
por: Kalle, Martina, et al.
Publicado: (2012) -
A Peptide of Heparin Cofactor II Inhibits Endotoxin-Mediated Shock and Invasive Pseudomonas aeruginosa Infection
por: Kalle, Martina, et al.
Publicado: (2014) -
Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria
por: Hansen, Finja C., et al.
Publicado: (2017) -
Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo
por: Saravanan, Rathi, et al.
Publicado: (2017) -
Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products
por: Petrlova, Jitka, et al.
Publicado: (2020)