Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer

BRCA1-associated RING domain protein 1 (BARD1) stabilizes BRCA1 protein by forming a heterodimeric RING-RING complex, and impacts function of BRCA1, including homologous recombination (HR) repair. Although colon cancer cells usually express wild type BRCA1, presence of an oncogenic BARD1 splice vari...

Descripción completa

Detalles Bibliográficos
Autores principales: Ozden, Ozkan, Bishehsari, Faraz, Bauer, Jessica, Park, Seong-Hoon, Jana, Arundhati, Baik, Seung Hyun, Sporn, Judith C., Staudacher, Jonas J., Yazici, Cemal, Krett, Nancy, Jung, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873788/
https://www.ncbi.nlm.nih.gov/pubmed/27197561
http://dx.doi.org/10.1038/srep26273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873788/
https://www.ncbi.nlm.nih.gov/pubmed/27197561
http://dx.doi.org/10.1038/srep26273

Ejemplares similares