Optimization, Production, and Characterization of a CpG-Oligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen

[Image: see text] We have synthesized and characterized a novel phosphorothioate CpG oligodeoxynucleotide (CpG ODN)-Ficoll conjugated nanoparticulate adjuvant, termed DV230-Ficoll. This adjuvant was constructed from an amine-functionalized-Ficoll, a heterobifunctional linker (succinimidyl-[(N-maleim...

Descripción completa

Detalles Bibliográficos
Autores principales: Milley, Bob, Kiwan, Radwan, Ott, Gary S., Calacsan, Carlo, Kachura, Melissa, Campbell, John D., Kanzler, Holger, Coffman, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873889/
https://www.ncbi.nlm.nih.gov/pubmed/27074387
http://dx.doi.org/10.1021/acs.bioconjchem.6b00107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873889/
https://www.ncbi.nlm.nih.gov/pubmed/27074387
http://dx.doi.org/10.1021/acs.bioconjchem.6b00107

Ejemplares similares