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Optimization, Production, and Characterization of a CpG-Oligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen

[Image: see text] We have synthesized and characterized a novel phosphorothioate CpG oligodeoxynucleotide (CpG ODN)-Ficoll conjugated nanoparticulate adjuvant, termed DV230-Ficoll. This adjuvant was constructed from an amine-functionalized-Ficoll, a heterobifunctional linker (succinimidyl-[(N-maleim...

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Detalles Bibliográficos
Autores principales:	Milley, Bob, Kiwan, Radwan, Ott, Gary S., Calacsan, Carlo, Kachura, Melissa, Campbell, John D., Kanzler, Holger, Coffman, Robert L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873889/ https://www.ncbi.nlm.nih.gov/pubmed/27074387 http://dx.doi.org/10.1021/acs.bioconjchem.6b00107

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