Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies (ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites. Here we use zinc-finger nucleases to genetically modify the multidrug resistance-1 transporter PfMDR1 at amino acids 86 an...

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Detalles Bibliográficos
Autores principales: Veiga, M. Isabel, Dhingra, Satish K., Henrich, Philipp P., Straimer, Judith, Gnädig, Nina, Uhlemann, Anne-Catrin, Martin, Rowena E., Lehane, Adele M., Fidock, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873939/
https://www.ncbi.nlm.nih.gov/pubmed/27189525
http://dx.doi.org/10.1038/ncomms11553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873939/
https://www.ncbi.nlm.nih.gov/pubmed/27189525
http://dx.doi.org/10.1038/ncomms11553

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