Cargando…

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies (ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites. Here we use zinc-finger nucleases to genetically modify the multidrug resistance-1 transporter PfMDR1 at amino acids 86 an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Veiga, M. Isabel, Dhingra, Satish K., Henrich, Philipp P., Straimer, Judith, Gnädig, Nina, Uhlemann, Anne-Catrin, Martin, Rowena E., Lehane, Adele M., Fidock, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873939/ https://www.ncbi.nlm.nih.gov/pubmed/27189525 http://dx.doi.org/10.1038/ncomms11553

Ejemplares similares

Monitoring PfMDR1 transport in Plasmodium falciparum
por: Reiling, Sarah J, et al.
Publicado: (2015)

Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport
por: Calçada, Carla, et al.
Publicado: (2020)

PfMDR2 and PfMDR5 are dispensable for Plasmodium falciparum asexual parasite multiplication but change in vitro susceptibility to anti-malarial drugs
por: van der Velden, Maarten, et al.
Publicado: (2015)

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1
por: Adjalley, Sophie H., et al.
Publicado: (2015)

Assessment of Plasmodium falciparum PfMDR1 transport rates using Fluo-4
por: Friedrich, O, et al.
Publicado: (2014)

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers
por: Eastman, Richard T., et al.
Publicado: (2016)

Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum
por: Duvalsaint, Marvin, et al.
Publicado: (2021)

PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 Mutations
por: Simon, Nina, et al.
Publicado: (2022)

PfMDR1: Mechanisms of Transport Modulation by Functional Polymorphisms
por: Ferreira, Pedro Eduardo, et al.
Publicado: (2011)

Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane
por: Kavishe, Reginald A, et al.
Publicado: (2009)

In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin
por: Njokah, Muturi J., et al.
Publicado: (2016)

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
por: Dogovski, Con, et al.
Publicado: (2015)

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections
por: Pillai, Dylan R, et al.
Publicado: (2012)

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT
por: Shafik, Sarah Heckmatt, et al.
Publicado: (2022)

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13
por: Gnädig, Nina F., et al.
Publicado: (2020)

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro
por: Straimer, Judith, et al.
Publicado: (2017)

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness
por: Dhingra, Satish K., et al.
Publicado: (2019)

Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance
por: Paloque, Lucie, et al.
Publicado: (2022)

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
por: Stokes, Barbara H, et al.
Publicado: (2021)

Plasmodium falciparum resistance to artemisinin-based combination therapies
por: Ward, Kurt E, et al.
Publicado: (2022)

Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum
por: Sharma, Aabha I., et al.
Publicado: (2020)

Structure and Drug Resistance of the Plasmodium falciparum Transporter PfCRT
por: Kim, Jonathan, et al.
Publicado: (2019)

A G358S mutation in the Plasmodium falciparum Na(+) pump PfATP4 confers clinically-relevant resistance to cipargamin
por: Qiu, Deyun, et al.
Publicado: (2022)

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
por: Mok, Sachel, et al.
Publicado: (2021)

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine
por: Dhingra, Satish K., et al.
Publicado: (2017)

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
por: Ross, Leila S., et al.
Publicado: (2018)

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology
por: Gabryszewski, Stanislaw J., et al.
Publicado: (2016)

Polymorphism analysis of pfmdr1 gene in Plasmodium falciparum isolates 11 years post-adoption of artemisinin-based combination therapy in Saudi Arabia
por: Al-Mekhlafi, Hesham M., et al.
Publicado: (2022)

Distribution of pfmdr1 polymorphisms in Plasmodium falciparum isolated from Southern Thailand
por: Mungthin, Mathirut, et al.
Publicado: (2014)

Histone acetyltransferase PfGCN5 regulates stress responsive and artemisinin resistance related genes in Plasmodium falciparum
por: Rawat, Mukul, et al.
Publicado: (2021)

Prevalence of Plasmodium falciparum anti-malarial resistance-associated polymorphisms in pfcrt, pfmdr1 and pfnhe1 in Muheza, Tanzania, prior to introduction of artemisinin combination therapy
por: Gadalla, Nahla B, et al.
Publicado: (2015)

Plasmodium falciparum: multifaceted resistance to artemisinins
por: Paloque, Lucie, et al.
Publicado: (2016)

Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum
por: Valderramos, Stephanie G., et al.
Publicado: (2010)

Plasmodium falciparum Drug Resistance Genes pfmdr1 and pfcrt In Vivo Co-Expression During Artemether-Lumefantrine Therapy
por: Silva, M., et al.
Publicado: (2022)

Laboratory Detection of Artemisinin-Resistant Plasmodium falciparum
por: Chotivanich, Kesinee, et al.
Publicado: (2014)

Mechanisms of artemisinin resistance in Plasmodium falciparum malaria
por: Suresh, Niraja, et al.
Publicado: (2018)

K13 mutations and pfmdr1 copy number variation in Plasmodium falciparum malaria in Myanmar
por: Win, Aye A., et al.
Publicado: (2016)

Role of Different Pfcrt and Pfmdr-1 Mutations in Conferring Resistance to Antimalaria Drugs in Plasmodium falciparum
por: Ibraheem, Zaid O., et al.
Publicado: (2014)

Prevalence of Plasmodium falciparum Pfcrt and Pfmdr1 alleles in settings with different levels of Plasmodium vivax co-endemicity in Ethiopia
por: Hailemeskel, Elifaged, et al.
Publicado: (2019)

Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya
por: Borrmann, Steffen, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ikkqeal0po92jgt9tivitn5k2d