Structure of human Cdc45 and implications for CMG helicase function

Cell division cycle protein 45 (Cdc45) is required for DNA synthesis during genome duplication, as a component of the Cdc45-MCM-GINS (CMG) helicase. Despite its essential biological function, its biochemical role in DNA replication has remained elusive. Here we report the 2.1-Å crystal structure of...

Descripción completa

Detalles Bibliográficos
Autores principales: Simon, Aline C., Sannino, Vincenzo, Costanzo, Vincenzo, Pellegrini, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873980/
https://www.ncbi.nlm.nih.gov/pubmed/27189187
http://dx.doi.org/10.1038/ncomms11638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873980/
https://www.ncbi.nlm.nih.gov/pubmed/27189187
http://dx.doi.org/10.1038/ncomms11638

Ejemplares similares