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Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype

BACKGROUND: Antigen (Ag)/IgE-mediated mast cell (MC) responses play detrimental roles in allergic diseases. MC activation via the high-affinity receptor for IgE (FcεRI) is controlled by the Src family kinase Lyn. Lyn-deficient (-/-) bone marrow-derived MCs (BMMCs) have been shown by various laborato...

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Detalles Bibliográficos
Autores principales: Nunes de Miranda, Susana M., Wilhelm, Thomas, Huber, Michael, Zorn, Carolin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874025/
https://www.ncbi.nlm.nih.gov/pubmed/27206658
http://dx.doi.org/10.1186/s12964-016-0135-0