Cargando…

Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype

BACKGROUND: Antigen (Ag)/IgE-mediated mast cell (MC) responses play detrimental roles in allergic diseases. MC activation via the high-affinity receptor for IgE (FcεRI) is controlled by the Src family kinase Lyn. Lyn-deficient (-/-) bone marrow-derived MCs (BMMCs) have been shown by various laborato...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nunes de Miranda, Susana M., Wilhelm, Thomas, Huber, Michael, Zorn, Carolin N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874025/ https://www.ncbi.nlm.nih.gov/pubmed/27206658 http://dx.doi.org/10.1186/s12964-016-0135-0

Ejemplares similares

Stimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells
por: Zorn, Carolin N., et al.
Publicado: (2018)

IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells
por: Gast, Mathias, et al.
Publicado: (2018)

Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1
por: Kanagy, William K., et al.
Publicado: (2022)

Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain
por: Chu, Erskine, et al.
Publicado: (2023)

TLR2 and TLR4 signaling in macrophages is negatively regulated by a Lyn-PI3K module and promoted by SHIP1
por: Keck, S, et al.
Publicado: (2009)

PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN
por: Liu, L, et al.
Publicado: (2014)

Dasatinib Inhibits Lyn and Fyn Src-Family Kinases in Mast Cells to Suppress Type I Hypersensitivity in Mice
por: Lee, Dajeong, et al.
Publicado: (2020)

Lyn prevents aberrant inflammatory responses to Pseudomonas infection in mammalian systems by repressing a SHIP-1-associated signaling cluster
por: Li, Rongpeng, et al.
Publicado: (2016)

Essential Role of Lyn in Fibrosis
por: Pham, Hung, et al.
Publicado: (2016)

Scrodentoid A Inhibits Mast Cell–Mediated Allergic Response by Blocking the Lyn–FcεRIβ Interaction
por: Qian, Fei, et al.
Publicado: (2019)

Negative Regulation of Immunoglobulin E–dependent Allergic Responses by Lyn Kinase
por: Odom, Sandra, et al.
Publicado: (2004)

Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells
por: Morinaga, Takao, et al.
Publicado: (2017)

Awards for Lyn Evans and Philippe Lebrun
Publicado: (2007)

The LHC Adventure -- Dr. Lyn Evans
por: CERN. Geneva
Publicado: (2009)

Streptochlorin Suppresses Allergic Dermatitis and Mast Cell Activation via Regulation of Lyn/Fyn and Syk Signaling Pathways in Cellular and Mouse Models
por: Lee, Seung-Hwan, et al.
Publicado: (2013)

GPI-anchored receptor clusters transiently recruit Lyn and Gα for temporary cluster immobilization and Lyn activation: single-molecule tracking study 1
por: Suzuki, Kenichi G.N., et al.
Publicado: (2007)

Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice
por: Scapini, Patrizia, et al.
Publicado: (2010)

Functions of the Lyn tyrosine kinase in health and disease
por: Ingley, Evan
Publicado: (2012)

Lyn Evans, l'homme du LHC
Publicado: (2009)

Immune Characteristics of LYN in Tumor Microenvironment of Gliomas
por: Jiang, Chonghua, et al.
Publicado: (2022)

A de novo nonsense mutation in the tyrosine kinase lyn in a patient with an early onset autoinflammatory phenotype
por: De Jesus, Adriana Almeida, et al.
Publicado: (2014)

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice
Publicado: (1996)

Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis
por: Peikert, Kevin, et al.
Publicado: (2021)

Loss of CD11b Accelerates Lupus Nephritis in Lyn-Deficient Mice Without Disrupting Glomerular Leukocyte Trafficking
por: Gottschalk, Timothy A., et al.
Publicado: (2022)

Kaempferol Suppresses the Activation of Mast Cells by Modulating the Expression of FcεRI and SHIP1
por: Nagata, Kazuki, et al.
Publicado: (2023)

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages
por: Freedman, Tanya S, et al.
Publicado: (2015)

Independent and Opposing Roles For Btk and Lyn in B and Myeloid Signaling Pathways
por: Satterthwaite, Anne B., et al.
Publicado: (1998)

Gomisin M2 Inhibits Mast Cell-Mediated Allergic Inflammation via Attenuation of FcεRI-Mediated Lyn and Fyn Activation and Intracellular Calcium Levels
por: Dhakal, Hima, et al.
Publicado: (2019)

Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells
Publicado: (1987)

Sustained Activation of Lyn Tyrosine Kinase In Vivo Leads to Autoimmunity
por: Hibbs, Margaret L., et al.
Publicado: (2002)

Inhibition of the B Cell by CD22: A Requirement for Lyn
por: Smith, Kenneth G.C., et al.
Publicado: (1998)

Lyn Evans, Peter jenni, Tejinder Virdee: BIG BANG
por: Giussani, Bruno
Publicado: (2007)

Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles
por: Li, Ming Yuan, et al.
Publicado: (2020)

A dominant function of LynB kinase in preventing autoimmunity
por: Brian, Ben F., et al.
Publicado: (2022)

Aspartoacylase suppresses prostate cancer progression by blocking LYN activation
por: Weng, Hong, et al.
Publicado: (2023)

SHIP deficiency causes Crohn's disease-like ileitis
por: Kerr, William G, et al.
Publicado: (2010)

Immunoglobulin E–dependent Active Fatal Anaphylaxis in Mast Cell–deficient Mice
por: Choi, Il Hwan, et al.
Publicado: (1998)

Mass dependence of branching ratios into HNL for FairShip
por: Graverini, Elena, et al.
Publicado: (2016)

Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells
por: Kuga, Takahisa, et al.
Publicado: (2020)

Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6–LYN gene fusion
por: Telford, N, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qfc31t28d3tqig4npjh4tv9qkc