PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL

PRDM14 is an epigenetic regulator known for maintaining embryonic stem cell identity and resetting potency in primordial germ cells. However, hematopoietic expression of Prdm14 at supraphysiological levels results in fully penetrant and rapid-onset T-cell acute lymphoblastic leukemia (T-ALL) in the...

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Detalles Bibliográficos
Autores principales: Carofino, Brandi L., Ayanga, Bernard, Tracey, Lauren J., Brooke-Bisschop, Travis, Justice, Monica J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874358/
https://www.ncbi.nlm.nih.gov/pubmed/27106930
http://dx.doi.org/10.1242/bio.017699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874358/
https://www.ncbi.nlm.nih.gov/pubmed/27106930
http://dx.doi.org/10.1242/bio.017699

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