TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

The murine thymus produces discrete γδ T cell subsets making either interferon-γ (IFN--γ) or interleukin 17 (IL-17), but the role of the TCR in this developmental process remains controversial. Here we show that mice haploinsufficient for both Cd3g and Cd3d (CD3DH, for CD3 double haploinsufficient)...

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Detalles Bibliográficos
Autores principales: Muñoz-Ruiz, Miguel, Ribot, Julie C., Grosso, Ana R., Gonçalves-Sousa, Natacha, Pamplona, Ana, Pennington, Daniel J., Regueiro, José R., Fernández-Malavé, Edgar, Silva-Santos, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875770/
https://www.ncbi.nlm.nih.gov/pubmed/27043412
http://dx.doi.org/10.1038/ni.3424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875770/
https://www.ncbi.nlm.nih.gov/pubmed/27043412
http://dx.doi.org/10.1038/ni.3424

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