FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric‐coated capsules in cynomolgus macaques

Although much speculation has surrounded intestinally expressed FcRn as a means for systemic uptake of orally administered immunoglobulin G (IgG), this has not been validated in translational models beyond neonates or in FcRn‐expressing cells in vitro. Recently, IgG1 intestinal infusion acutely in a...

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Detalles Bibliográficos
Autores principales: Muzammil, Salman, Mabus, John R., Cooper, Philip R., Brezski, Randall J., Bement, Courtney B., Perkinson, Rob, Huebert, Norman D., Thompson, Suzanne, Levine, Dalia, Kliwinski, Connie, Bradley, Dino, Hornby, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876138/
https://www.ncbi.nlm.nih.gov/pubmed/27433338
http://dx.doi.org/10.1002/prp2.218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876138/
https://www.ncbi.nlm.nih.gov/pubmed/27433338
http://dx.doi.org/10.1002/prp2.218

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