Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

Since recent publications suggested that the survival of cancer cells depends on MTH1 to avoid incorporation of oxidized nucleotides into the cellular DNA, MTH1 has attracted attention as a potential cancer therapeutic target. In this study, we identified new purine-based MTH1 inhibitors by chemical...

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Detalles Bibliográficos
Autores principales: Kawamura, Tatsuro, Kawatani, Makoto, Muroi, Makoto, Kondoh, Yasumitsu, Futamura, Yushi, Aono, Harumi, Tanaka, Miho, Honda, Kaori, Osada, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876372/
https://www.ncbi.nlm.nih.gov/pubmed/27210421
http://dx.doi.org/10.1038/srep26521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876372/
https://www.ncbi.nlm.nih.gov/pubmed/27210421
http://dx.doi.org/10.1038/srep26521

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