TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits12

Transcription factor EB (TFEB) was recently shown to be a master regulator of autophagy lysosome pathway. Here, we successfully generated and characterized transgenic mice overexpressing flag-TFEB. Enhanced autophagy in the flag-TFEB transgenic mice was confirmed by an increase in the cellular autop...

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Detalles Bibliográficos
Autores principales: Wang, Hongjie, Wang, Ruizhi, Carrera, Ivan, Xu, Shaohua, Lakshmana, Madepalli K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2016
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876487/
https://www.ncbi.nlm.nih.gov/pubmed/27257626
http://dx.doi.org/10.1523/ENEURO.0042-16.2016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876487/
https://www.ncbi.nlm.nih.gov/pubmed/27257626
http://dx.doi.org/10.1523/ENEURO.0042-16.2016

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