The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice

Cystic fibrosis (CF) is the result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CF-related diabetes affects 50% of adult CF patients. How CFTR deficiency predisposes to diabetes is unknown. Herein, we examined the impact of the most frequent cftr mutation in humans...

Descripción completa

Detalles Bibliográficos
Autores principales: Fontés, Ghislaine, Ghislain, Julien, Benterki, Isma, Zarrouki, Bader, Trudel, Dominique, Berthiaume, Yves, Poitout, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876763/
https://www.ncbi.nlm.nih.gov/pubmed/26283735
http://dx.doi.org/10.2337/db14-0810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876763/
https://www.ncbi.nlm.nih.gov/pubmed/26283735
http://dx.doi.org/10.2337/db14-0810

Ejemplares similares