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The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice

Cystic fibrosis (CF) is the result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CF-related diabetes affects 50% of adult CF patients. How CFTR deficiency predisposes to diabetes is unknown. Herein, we examined the impact of the most frequent cftr mutation in humans...

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Detalles Bibliográficos
Autores principales:	Fontés, Ghislaine, Ghislain, Julien, Benterki, Isma, Zarrouki, Bader, Trudel, Dominique, Berthiaume, Yves, Poitout, Vincent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2015
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876763/ https://www.ncbi.nlm.nih.gov/pubmed/26283735 http://dx.doi.org/10.2337/db14-0810

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