Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells

PPAR-γ is essential for differentiation of hepatic stellate cells (HSC), and its loss due to epigenetic repression by methyl-CpG binding protein 2 (MeCP2) causes HSC myofibroblastic activation mediated in part via Wnt pathway, the key cellular event in liver fibrosis. Decreased miR-132 was previousl...

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Detalles Bibliográficos
Autores principales: Kweon, Soo-Mi, Chi, Feng, Higashiyama, Reiichi, Lai, Keane, Tsukamoto, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877088/
https://www.ncbi.nlm.nih.gov/pubmed/27214381
http://dx.doi.org/10.1371/journal.pone.0156111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877088/
https://www.ncbi.nlm.nih.gov/pubmed/27214381
http://dx.doi.org/10.1371/journal.pone.0156111

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