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Synergy of AMPA and NMDA Receptor Currents in Dopaminergic Neurons: A Modeling Study

Dopaminergic (DA) neurons display two modes of firing: low-frequency tonic and high-frequency bursts. The high frequency firing within the bursts is attributed to NMDA, but not AMPA receptor activation. In our models of the DA neuron, both biophysical and abstract, the NMDA receptor current can sign...

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Detalles Bibliográficos
Autores principales: Zakharov, Denis, Lapish, Christopher, Gutkin, Boris, Kuznetsov, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877376/
https://www.ncbi.nlm.nih.gov/pubmed/27252643
http://dx.doi.org/10.3389/fncom.2016.00048