Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functionality of genetic elements, creating genetically modified organisms as well as preclinical research of genetic disorders. However, the high frequency of off-target activity (≥50%)—RGEN (RNA-guided endonu...

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Detalles Bibliográficos
Autores principales: Zhang, Xiao-Hui, Tee, Louis Y, Wang, Xiao-Gang, Huang, Qun-Shan, Yang, Shi-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877446/
https://www.ncbi.nlm.nih.gov/pubmed/26575098
http://dx.doi.org/10.1038/mtna.2015.37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877446/
https://www.ncbi.nlm.nih.gov/pubmed/26575098
http://dx.doi.org/10.1038/mtna.2015.37

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