Novel Mutations in MLH1 and MSH2 Genes in Mexican Patients with Lynch Syndrome

Background. Lynch Syndrome (LS) is characterized by germline mutations in the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. This syndrome is inherited in an autosomal dominant pattern and is characterized by early onset colorectal cancer (CRC) and extracolonic tumors. The aim of this s...

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Detalles Bibliográficos
Autores principales: Moreno-Ortiz, Jose Miguel, Ayala-Madrigal, María de la Luz, Corona-Rivera, Jorge Román, Centeno-Flores, Manuel, Maciel-Gutiérrez, Víctor, Franco-Topete, Ramón Antonio, Armendáriz-Borunda, Juan, Hotchkiss, Erin, Pérez-Carbonell, Lucia, Rhees, Jennifer, Boland, Clement Richard, Gutiérrez-Angulo, Melva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877485/
https://www.ncbi.nlm.nih.gov/pubmed/27247567
http://dx.doi.org/10.1155/2016/5278024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877485/
https://www.ncbi.nlm.nih.gov/pubmed/27247567
http://dx.doi.org/10.1155/2016/5278024

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