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A New Defective Helper RNA to Produce Recombinant Sindbis Virus that Infects Neurons but does not Propagate

Recombinant Sindbis viruses are important tools in neuroscience because they combine rapid and high transgene expression with a capacity to carry large transgenes. Currently, two packaging systems based on the defective helper (DH) RNAs DH(26S)5’SIN and DH-BB(tRNA;TE12) are available for generating...

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Detalles Bibliográficos
Autores principales: Kebschull, Justus M., Garcia da Silva, Pedro, Zador, Anthony M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877524/
https://www.ncbi.nlm.nih.gov/pubmed/27252627
http://dx.doi.org/10.3389/fnana.2016.00056