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l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines

BACKGROUND: Myeloproliferative neoplasms are Philadelphia chromosome-negative diseases characterized by hyperproliferation of mature myeloid cells, associated or not with the Janus kinase 2 tyrosine kinase mutation, JAK2V617F. As there is no curative therapy, researchers have been investigating new...

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Detalles Bibliográficos
Autores principales: Tavares, Cristiane, Maciel, Thaís, Burin, Sandra, Ambrósio, Luciana, Ghisla, Sandro, Sampaio, Suely, Castro, Fabíola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Hematologia e Hemoterapia 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877619/
https://www.ncbi.nlm.nih.gov/pubmed/27208571
http://dx.doi.org/10.1016/j.bjhh.2016.03.004