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PI3K p110β subunit in leptin receptor expressing cells is required for the acute hypophagia induced by endotoxemia

OBJECTIVE: Hypophagia and increased energy expenditure under inflammatory conditions, such as that observed after bacterial lipopolysaccharide (LPS) administration, are associated with leptin secretion. The hypophagic effect of leptin depends in part on the activation of PI3K signaling pathway. Howe...

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Detalles Bibliográficos
Autores principales: Borges, Beatriz C., Garcia-Galiano, David, Rorato, Rodrigo, Elias, Lucila L.K., Elias, Carol F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877663/
https://www.ncbi.nlm.nih.gov/pubmed/27257598
http://dx.doi.org/10.1016/j.molmet.2016.03.003