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Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease

OBJECTIVE: Normal adipose tissue growth and function is critical to maintaining metabolic homeostasis and its excess (e.g. obesity) or absence (e.g. lipodystrophy) is associated with severe metabolic disease. The goal of this study was to understand the mechanisms maintaining healthy adipose tissue...

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Detalles Bibliográficos
Autores principales: Lee, Peter L., Tang, Yuefeng, Li, Huawei, Guertin, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877665/
https://www.ncbi.nlm.nih.gov/pubmed/27257602
http://dx.doi.org/10.1016/j.molmet.2016.04.001