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Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids
BACKGROUND: De novo production of multi-hydroxylated diterpenoids is challenging due to the lack of efficient redox systems. RESULTS: In this study a new reductase/ferredoxin system from Streptomyces afghaniensis (AfR·Afx) was identified, which allowed the Escherichia coli-based production of the tr...
Autores principales: | Görner, Christian, Schrepfer, Patrick, Redai, Veronika, Wallrapp, Frank, Loll, Bernhard, Eisenreich, Wolfgang, Haslbeck, Martin, Brück, Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877809/ https://www.ncbi.nlm.nih.gov/pubmed/27216162 http://dx.doi.org/10.1186/s12934-016-0487-6 |
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