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The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
BACKGROUND: Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and it serves as a scaffold protein for Elongin B and C, Rbx1 and various substrat...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878042/ https://www.ncbi.nlm.nih.gov/pubmed/27222660 http://dx.doi.org/10.1186/s13008-016-0020-7 |