Proofreading neutralizes potential error hotspots in genetic code translation by transfer RNAs

The ribosome uses initial and proofreading selection of aminoacyl-tRNAs for accurate protein synthesis. Anomalously high initial misreading in vitro of near-cognate codons by tRNA(His) and tRNA(Glu) suggested potential error hotspots in protein synthesis, but in vivo data suggested their partial neu...

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Detalles Bibliográficos
Autores principales: Zhang, Jingji, Ieong, Ka-Weng, Mellenius, Harriet, Ehrenberg, Måns
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878615/
https://www.ncbi.nlm.nih.gov/pubmed/27090284
http://dx.doi.org/10.1261/rna.055632.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878615/
https://www.ncbi.nlm.nih.gov/pubmed/27090284
http://dx.doi.org/10.1261/rna.055632.115

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