Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma

Several important biological activities have been attributed to the pentacyclic triterpene ursolic acid (UA), being its antitumoral effect extensively studied in human adenocarcinomas. In this work, we focused on the efficacy and molecular mechanisms involved in the antitumoral effects of UA, as sin...

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Detalles Bibliográficos
Autores principales: Villar, Victor Hugo, Vögler, Oliver, Barceló, Francisca, Martín-Broto, Javier, Martínez-Serra, Jordi, Ruiz-Gutiérrez, Valentina, Alemany, Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878803/
https://www.ncbi.nlm.nih.gov/pubmed/27219337
http://dx.doi.org/10.1371/journal.pone.0155946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878803/
https://www.ncbi.nlm.nih.gov/pubmed/27219337
http://dx.doi.org/10.1371/journal.pone.0155946

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