Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

HIGHLIGHTS: ASS234 is a MTDL compound containing a moiety from Donepezil and the propargyl group from the PF 9601N, a potent and selective MAO B inhibitor. This compound is the most advanced anti-Alzheimer agent for preclinical studies identified in our laboratory. Derived from ASS234 both multipote...

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Detalles Bibliográficos
Autores principales: Unzeta, Mercedes, Esteban, Gerard, Bolea, Irene, Fogel, Wieslawa A., Ramsay, Rona R., Youdim, Moussa B. H., Tipton, Keith F., Marco-Contelles, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879129/
https://www.ncbi.nlm.nih.gov/pubmed/27252617
http://dx.doi.org/10.3389/fnins.2016.00205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879129/
https://www.ncbi.nlm.nih.gov/pubmed/27252617
http://dx.doi.org/10.3389/fnins.2016.00205

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