Cargando…

TCR signaling by conventional CD4(+) T cells is required for optimal maintenance of peripheral regulatory T cell numbers

To maintain immune tolerance, regulatory T cell (Treg) numbers must be closely indexed to the number of conventional T cells (Tconvs) so that an adequate Treg:Tconv ratio can be maintained. Two factors important in this process are the cytokine interleukin‐2 (IL‐2) and T cell receptor (TCR) stimulat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leichner, Theresa M., Satake, Atsushi, Kambayashi, Taku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879461/ https://www.ncbi.nlm.nih.gov/pubmed/27891224 http://dx.doi.org/10.1002/iid3.100

Ejemplares similares

Inhibition of Calcineurin Abrogates While Inhibition of mTOR Promotes Regulatory T Cell Expansion and Graft-Versus-Host Disease Protection by IL-2 in Allogeneic Bone Marrow Transplantation
por: Satake, Atsushi, et al.
Publicado: (2014)

The clone size of peripheral CD8 T cells is regulated by TCR promiscuity
por: Hao, Yi, et al.
Publicado: (2006)

CD4(+) regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
por: Friedline, Randall H., et al.
Publicado: (2009)

CD4(+) regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
por: Friedline, Randall H., et al.
Publicado: (2009)

Distinct Features of Canine Non-conventional CD4(−)CD8α(−) Double-Negative TCRαβ(+) vs. TCRγδ(+) T Cells
por: Rabiger, Friederike V., et al.
Publicado: (2019)

CD8(+) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine
por: Cho, Hyoung-Soo, et al.
Publicado: (2020)

Rapamycin and abundant TCR stimulation are required for the generation of stable human induced regulatory T cells
por: Kim, Juewan, et al.
Publicado: (2020)

Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
por: Mikami, Norihisa, et al.
Publicado: (2020)

Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth
por: Fujimura, Taku, et al.
Publicado: (2012)

Effects of conventional therapeutic interventions on the number and function of regulatory T cells
por: Roselli, Mario, et al.
Publicado: (2013)

ZFP91 is required for the maintenance of regulatory T cell homeostasis and function
por: Wang, Aiting, et al.
Publicado: (2020)

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity
por: Azzam, Hala S., et al.
Publicado: (1998)

Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains
Publicado: (1994)

Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms
por: Presotto, Danilo, et al.
Publicado: (2017)

Essential Roles of CD8(+)CD122(+) Regulatory T Cells in the Maintenance of T Cell Homeostasis
por: Rifa'i, Muhaimin, et al.
Publicado: (2004)

Enhanced TCR-induced Apoptosis in Interferon Regulatory Factor 4–deficient CD4(+) Th Cells
por: Lohoff, Michael, et al.
Publicado: (2004)

Circulating gluten‐specific, but not CMV‐specific, CD39(+) regulatory T cells have an oligoclonal TCR repertoire
por: Cook, Laura, et al.
Publicado: (2020)

The 3’-Jα Region of the TCRα Locus Bears Gene Regulatory Activity in Thymic and Peripheral T Cells
por: Kučerová-Levisohn, Martina, et al.
Publicado: (2015)

Lymph act, TCR αβ, TCR γδ cells in peripheral blood in children with juvenile idiopathic arthritis
por: Mazur-Zielinska, H
Publicado: (2008)

Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4(+) T cell homeostasis
por: Borlido, Joana, et al.
Publicado: (2018)

SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells
por: Kuwabara, Taku, et al.
Publicado: (2021)

Commitment of Immature CD4(+)8(+) Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains
por: Suzuki, Harumi, et al.
Publicado: (1997)

Regulatory T Cell–Derived TRAIL Is Not Required for Peripheral Tolerance
por: Dadey, Rebekah E., et al.
Publicado: (2021)

Maintenance of the EBV-specific CD8(+) TCRαβ repertoire in immunosuppressed lung transplant recipients
por: Nguyen, Thi HO, et al.
Publicado: (2017)

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
por: Wong, Jamie, et al.
Publicado: (2007)

Impact of the TCR Signal on Regulatory T Cell Homeostasis, Function, and Trafficking
por: Kim, Joong Kyu, et al.
Publicado: (2009)

Biophysical Characterization of CD6—TCR/CD3 Interplay in T Cells
por: Meddens, Marjolein B. M., et al.
Publicado: (2018)

GATA-3 controls T cell maintenance and proliferation downstream of TCR and cytokine signals
por: Wang, Yunqi, et al.
Publicado: (2013)

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex
Publicado: (1991)

TCR ITAM multiplicity is required for the generation of follicular helper T-cells
por: Hwang, SuJin, et al.
Publicado: (2015)

TCR-triggered extracellular superoxide production is not required for T-cell activation
por: Belikov, Aleksey V, et al.
Publicado: (2014)

PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling
por: Tanaka, Yukinori, et al.
Publicado: (2020)

Successful Treatment of Advanced Primary Cutaneous Peripheral T-Cell Lymphoma with Oral Bexarotene Monotherapy
por: Sato, Yota, et al.
Publicado: (2018)

Higher Sensitivity of Foxp3(+) Treg Compared to Foxp3(-) Conventional T Cells to TCR-Independent Signals for CD69 Induction
por: Bremser, Anna, et al.
Publicado: (2015)

Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity
por: Levine, Andrew G., et al.
Publicado: (2017)

T follicular helper and T follicular regulatory cells have different TCR specificity
por: Maceiras, Ana Raquel, et al.
Publicado: (2017)

Regulatory T cells and co‐evolution of allele‐specific MHC recognition by the TCR
por: Steele, Edward J., et al.
Publicado: (2019)

Sarcoidosis-Lymphoma Syndrome Associated with Folliculotropic Peripheral T Cell Lymphoma Not Otherwise Specified
por: Yoshida, Saaya, et al.
Publicado: (2017)

Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans
por: van der Geest, Kornelis S M, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_s4nrlichbd3t3o9q9sngg49n8f