Prospective Design of Anti‐Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain

Anti‐transferrin receptor (TfR)‐based bispecific antibodies have shown promise for boosting antibody uptake in the brain. Nevertheless, there are limited data on the molecular properties, including affinity required for successful development of TfR‐based therapeutics. A complex nonmonotonic relatio...

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Detalles Bibliográficos
Autores principales: Kanodia, JS, Gadkar, K, Bumbaca, D, Zhang, Y, Tong, RK, Luk, W, Hoyte, K, Lu, Y, Wildsmith, KR, Couch, JA, Watts, RJ, Dennis, MS, Ernst, JA, Scearce‐Levie, K, Atwal, JK, Ramanujan, S, Joseph, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879477/
https://www.ncbi.nlm.nih.gov/pubmed/27299941
http://dx.doi.org/10.1002/psp4.12081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879477/
https://www.ncbi.nlm.nih.gov/pubmed/27299941
http://dx.doi.org/10.1002/psp4.12081

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