Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1

Camptothecin (CPT), a topoisomerase I (TOP1) inhibitor, exhibits anti-tumor activity against a wide range of tumors. Redundancy of TOP1-mediated repair mechanisms is a major challenge facing the efficiency of TOP1-targetting therapies. This study aims to uncover new TOP1 targeting approaches utilisi...

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Detalles Bibliográficos
Autores principales: Elsayed, Waheba, El-Shafie, Lamia, Hassan, Mohamed K., Farag, Mohamed A., El-Khamisy, Sherif F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879542/
https://www.ncbi.nlm.nih.gov/pubmed/27220325
http://dx.doi.org/10.1038/srep26626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879542/
https://www.ncbi.nlm.nih.gov/pubmed/27220325
http://dx.doi.org/10.1038/srep26626

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