Increased sensitivity of BRCA defective triple negative breast tumors to plumbagin through induction of DNA Double Strand Breaks (DSB)

We have earlier shown that Plumbagin (PB) can induce selective cytotoxicity to BRCA1 defective ovarian cancer cells; however, the effect of this molecule in BRCA1 mutated breast cancers has not been analyzed yet. Here, we report that reactive oxygen species (ROS) induced by PB resulted in DNA DSB an...

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Detalles Bibliográficos
Autores principales: Nair, Rakesh Sathish, Kumar, Jerald Mahesh, Jose, Jedy, Somasundaram, Veena, Hemalatha, Sreelatha K., Sengodan, Satheesh Kumar, Nadhan, Revathy, Anilkumar, Thapasimuthu V., Srinivas, Priya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879579/
https://www.ncbi.nlm.nih.gov/pubmed/27220670
http://dx.doi.org/10.1038/srep26631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879579/
https://www.ncbi.nlm.nih.gov/pubmed/27220670
http://dx.doi.org/10.1038/srep26631

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