Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infection

Comparative analysis of the Clostridium difficile BI/NAP1/027 strain R20291 and ClosTron-derived ermB mutants in the hamster infection model are compromised by the clindamycin susceptibility of the parent. Mutants can appear more virulent. We have rectified this anomaly by genome engineering. The va...

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Detalles Bibliográficos
Autores principales: Kelly, Michelle L., Ng, Yen Kuan, Cartman, Stephen T., Collery, Mark M., Cockayne, Alan, Minton, Nigel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879870/
https://www.ncbi.nlm.nih.gov/pubmed/26946361
http://dx.doi.org/10.1016/j.anaerobe.2016.02.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879870/
https://www.ncbi.nlm.nih.gov/pubmed/26946361
http://dx.doi.org/10.1016/j.anaerobe.2016.02.011

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