Cargando…

Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infection

Comparative analysis of the Clostridium difficile BI/NAP1/027 strain R20291 and ClosTron-derived ermB mutants in the hamster infection model are compromised by the clindamycin susceptibility of the parent. Mutants can appear more virulent. We have rectified this anomaly by genome engineering. The va...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kelly, Michelle L., Ng, Yen Kuan, Cartman, Stephen T., Collery, Mark M., Cockayne, Alan, Minton, Nigel P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879870/ https://www.ncbi.nlm.nih.gov/pubmed/26946361 http://dx.doi.org/10.1016/j.anaerobe.2016.02.011

Ejemplares similares

Reconsidering the Sporulation Characteristics of Hypervirulent Clostridium difficile BI/NAP1/027
por: Burns, David A., et al.
Publicado: (2011)

Infection of hamsters with the UK Clostridium difficile ribotype 027 outbreak strain R20291
por: Buckley, Anthony M., et al.
Publicado: (2011)

Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
por: Kuehne, Sarah A., et al.
Publicado: (2014)

Impact of Phage CDHS-1 on the Transcription, Physiology and Pathogenicity of a Clostridioides difficile Ribotype 027 Strain, R20291
por: Nale, Janet Y., et al.
Publicado: (2021)

Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital
por: Morfin-Otero, Rayo, et al.
Publicado: (2015)

The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains
por: Dawson, Lisa F, et al.
Publicado: (2011)

Comparative biofilm-forming ability between Clostridioides difficile strains isolated in Latin America and the epidemic NAP1/027 strain
por: Morais, Maria Luana Gaudencio dos Santos, et al.
Publicado: (2022)

Risk Factors for BI/NAP1/027 Clostridioides difficile Infections and Clinical Outcomes Compared With Non-NAP1 Strains
por: Mani, Nandita S, et al.
Publicado: (2019)

Prevalence of Hypervirulent BI/NAP1/027 Clostridium difficile Strains in Cali-Colombia
por: Rosso, Fernando, et al.
Publicado: (2017)

The Hypervirulent Strain of Clostridium Difficile: NAP1/B1/027 - A Brief Overview
por: Fatima, Rawish, et al.
Publicado: (2019)

Expanding the Repertoire of Gene Tools for Precise Manipulation of the Clostridium difficile Genome: Allelic Exchange Using pyrE Alleles
por: Ng, Yen Kuan, et al.
Publicado: (2013)

First Report of Clostridium difficile NAP1/027 in a Mexican Hospital
por: Camacho-Ortiz, Adrián, et al.
Publicado: (2015)

1120. Clostridium difficile Infection Risk Factors, Severity, and Outcomes in Patients Infected with NAP1/027 Strain in a Non-Epidemic Setting
por: Nahar, Julie
Publicado: (2018)

Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291
por: Girinathan, Brintha P., et al.
Publicado: (2017)

The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile
por: Carter, Glen P., et al.
Publicado: (2011)

748. The Changing Epidemiology of Clostridioides difficile Infection and the NAP1/027 Strain in Two Quebec Hospitals
por: Couture, Sandrine, et al.
Publicado: (2021)

Correction: First Report of Clostridium difficile NAP1/027 in a Mexican Hospital
por: Camacho-Ortiz, Adrián, et al.
Publicado: (2015)

Characterization of Exosporium Layer Variability of Clostridioides difficile Spores in the Epidemically Relevant Strain R20291
por: Pizarro-Guajardo, Marjorie, et al.
Publicado: (2020)

The Role of Flagella in Clostridium difficile Pathogenesis: Comparison between a Non-Epidemic and an Epidemic Strain
por: Baban, Soza T., et al.
Publicado: (2013)

What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes
por: Monteford, Jorge, et al.
Publicado: (2021)

479. Trends in C. difficile Incidence, Mortality, and NAP1/027 Strain in the Population of Monroe County, New York
por: Hatwar, Trupti, et al.
Publicado: (2018)

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile
por: Dong, Qiwen, et al.
Publicado: (2023)

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile
por: Dong, Qiwen, et al.
Publicado: (2023)

Clostridium difficile 027/BI/NAP1 Encodes a Hypertoxic and Antigenically Variable Form of TcdB
por: Lanis, Jordi M., et al.
Publicado: (2013)

What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives
por: Collery, Mark M., et al.
Publicado: (2016)

Epidemic Clostridium difficile Ribotype 027 in Chile
por: Hernández-Rocha, Cristian, et al.
Publicado: (2012)

Origin, genomic diversity and microevolution of the Clostridium difficile B1/NAP1/RT027/ST01 strain in Costa Rica, Chile, Honduras and Mexico
por: Guerrero-Araya, Enzo, et al.
Publicado: (2020)

Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker
por: Heap, John T., et al.
Publicado: (2012)

Development of Clostridium difficile R20291ΔPaLoc model strains and in vitro methodologies reveals CdtR is required for the production of CDT to cytotoxic levels
por: Bilverstone, T.W., et al.
Publicado: (2017)

Emergence of a highly resistant Clostridium difficile strain (NAP/BI/027) in a tertiary care center in Saudi Arabia
por: Alzahrani, Nabeel, et al.
Publicado: (2013)

Characterization of the Adherence of Clostridium difficile Spores: The Integrity of the Outermost Layer Affects Adherence Properties of Spores of the Epidemic Strain R20291 to Components of the Intestinal Mucosa
por: Mora-Uribe, Paola, et al.
Publicado: (2016)

Epidemic Clostridioides difficile Ribotype 027 Lineages: Comparisons of Texas Versus Worldwide Strains
por: Endres, Bradley T, et al.
Publicado: (2019)

Whole genome analysis reveals new insights into the molecular characteristics of Clostridioides difficile NAP1/BI/027/ST1 clinical isolates in the People’s Republic of China
por: Lv, Tao, et al.
Publicado: (2019)

In vivo animal models confirm an increased virulence potential and pathogenicity of the NAP1/RT027/ST01 genotype within the Clostridium difficile MLST Clade 2
por: Orozco-Aguilar, Josué, et al.
Publicado: (2020)

Unique Clindamycin-Resistant Clostridioides difficile Strain Related to Fluoroquinolone-Resistant Epidemic BI/RT027 Strain
por: Skinner, Andrew M., et al.
Publicado: (2020)

Spores of Clostridium difficile Clinical Isolates Display a Diverse Germination Response to Bile Salts
por: Heeg, Daniela, et al.
Publicado: (2012)

Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors
por: López-Ureña, Diana, et al.
Publicado: (2019)

Genome characterization of a novel binary toxin-positive strain of Clostridium difficile and comparison with the epidemic 027 and 078 strains
por: Peng, Zhong, et al.
Publicado: (2017)

Mechanistic insights into Long COVID in hamsters
por: Minton, Kirsty
Publicado: (2022)

Deciphering Adaptation Strategies of the Epidemic Clostridium difficile 027 Strain during Infection through In Vivo Transcriptional Analysis
por: Kansau, Imad, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_j8fag41vhdq1d7paojc1n46a9j