Mimicking Cdk2 phosphorylation of Bcl-xL at Ser73 results in caspase activation and Bcl-xL cleavage

Cisplatin is a widely used chemotherapeutic agent, yet its efficacy is limited by nephrotoxicity. The severity of nephrotoxicity is associated with the extent of kidney cell death. Previously, we found that cisplatin-induced kidney cell death was dependent on Cdk2 activation, and inhibition of Cdk2...

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Detalles Bibliográficos
Autores principales: Seng, NS, Megyesi, J, Tarcsafalvi, A, Price, PM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880054/
https://www.ncbi.nlm.nih.gov/pubmed/27239332
http://dx.doi.org/10.1038/cddiscovery.2016.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880054/
https://www.ncbi.nlm.nih.gov/pubmed/27239332
http://dx.doi.org/10.1038/cddiscovery.2016.1

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