CRISPR-Mediated Slamf1(Δ/Δ) Slamf5(Δ/Δ) Slamf6(Δ/Δ) Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects

SAP (SH2D1A) is required intrinsically in CD4 T cells to generate germinal center responses and long-term humoral immunity. SAP binds to SLAM family receptors, including SLAM, CD84, and Ly108 to enhance cytokine secretion and sustained T cell:B cell adhesion, which both improve T follicular helper (...

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Detalles Bibliográficos
Autores principales: Hu, Joyce K., Crampton, Jordan C., Locci, Michela, Crotty, Shane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880187/
https://www.ncbi.nlm.nih.gov/pubmed/27223891
http://dx.doi.org/10.1371/journal.pone.0156074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880187/
https://www.ncbi.nlm.nih.gov/pubmed/27223891
http://dx.doi.org/10.1371/journal.pone.0156074

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