New treatment option for ovarian cancer: PARP inhibitors

Poly(ADP-ribose) polymerase (PARP), which was first described over 50 years ago by Mandel, are a family of protein enzymes involved in DNA damage response and works by recognizing the single-strand DNA break (ssDNA) and then effecting DNA repair. A double-strand DNA (dsDNA) break can be repaired by...

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Detalles Bibliográficos
Autores principales: Meehan, Robert S., Chen, Alice P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880823/
https://www.ncbi.nlm.nih.gov/pubmed/27231574
http://dx.doi.org/10.1186/s40661-016-0024-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880823/
https://www.ncbi.nlm.nih.gov/pubmed/27231574
http://dx.doi.org/10.1186/s40661-016-0024-7

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