Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation

BACKGROUND: Ultraviolet-B (UVB) exposure attributes to the formation of age-related nuclear cataract (ARNC), which is mediated with DNA damage. DNA damage, an important factor for pathogenesis of ARNC, is induced by UVB, and is generally resolved by the nucleotide excision repair (NER) repair mechan...

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Detalles Bibliográficos
Autores principales: Wang, Yong, Li, Fei, Zhang, Guowei, Kang, Lihua, Guan, Huaijin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880862/
https://www.ncbi.nlm.nih.gov/pubmed/27231489
http://dx.doi.org/10.1186/s13148-016-0229-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880862/
https://www.ncbi.nlm.nih.gov/pubmed/27231489
http://dx.doi.org/10.1186/s13148-016-0229-y

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