Characterisation of the DNA sequence specificity, cellular toxicity and cross-linking properties of novel bispyridine-based dinuclear platinum complexes

BACKGROUND: The anti-tumour activity of cisplatin is thought to be a result of its capacity to form DNA adducts which prevent cellular processes such as DNA replication and transcription. These DNA adducts can effectively induce cancer cell death, however, there are a range of clinical side effects...

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Detalles Bibliográficos
Autores principales: Johnson, Ben W., Murray, Vincent, Temple, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880875/
https://www.ncbi.nlm.nih.gov/pubmed/27225032
http://dx.doi.org/10.1186/s12885-016-2368-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880875/
https://www.ncbi.nlm.nih.gov/pubmed/27225032
http://dx.doi.org/10.1186/s12885-016-2368-0

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