Successful use of next generation genomic sequencing (NGS)-directed therapy of clear cell carcinoma of the ovary (CCCO) with trametinib and metformin in a patient with chemotherapy-refractory disease

PURPOSE: Compared to other subtypes of epithelial ovarian cancer, clear cell carcinoma of the ovary bears an ominous reputation for chemotherapy resistance, increased relapse rate, and diminished survival. Among patients with distinct histopathologic subtypes, molecular analyses have identified a va...

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Detalles Bibliográficos
Autores principales: Castro, Michael P., Whitcomb, Bradford P., Zajchowski, Deborah A., Coleman, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880882/
https://www.ncbi.nlm.nih.gov/pubmed/27231564
http://dx.doi.org/10.1186/s40661-015-0013-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880882/
https://www.ncbi.nlm.nih.gov/pubmed/27231564
http://dx.doi.org/10.1186/s40661-015-0013-2

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