Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers

Promoter CpG methylation is a fundamental regulatory process of gene expression. TET proteins are active CpG demethylases converting 5-methylcytosine to 5-hydroxymethylcytosine, with loss of 5 hmC as an epigenetic hallmark of cancers, indicating critical roles of TET proteins in epigenetic tumorigen...

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Detalles Bibliográficos
Autores principales: Li, Lili, Li, Chen, Mao, Haitao, Du, Zhenfang, Chan, Wai Yee, Murray, Paul, Luo, Bing, Chan, Anthony TC, Mok, Tony SK, Chan, Francis KL, Ambinder, Richard F, Tao, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880909/
https://www.ncbi.nlm.nih.gov/pubmed/27225590
http://dx.doi.org/10.1038/srep26591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880909/
https://www.ncbi.nlm.nih.gov/pubmed/27225590
http://dx.doi.org/10.1038/srep26591

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