Preparation and evaluation of rotigotine-loaded implant for the treatment of Parkinson’s disease and its evolution study

PURPOSE: To develop rotigotine-loaded implants (RI) to achieve continuous release of rotigotine for long duration for the treatment of Parkinson’s disease (PD). METHODS: RI was prepared by hot-melt extrusion method using poly (lactide-co-glycolide) (PLGA) as the matrix. In vitro drug release was opt...

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Detalles Bibliográficos
Autores principales: Wang, Aiping, Liu, Yanxiang, Liang, Rongcai, Zhang, Xuemei, Sun, Kaoxiang, Wu, Zimei, Liu, Wanhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Pharmaceutical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881155/
https://www.ncbi.nlm.nih.gov/pubmed/27275128
http://dx.doi.org/10.1016/j.jsps.2016.04.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881155/
https://www.ncbi.nlm.nih.gov/pubmed/27275128
http://dx.doi.org/10.1016/j.jsps.2016.04.022

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