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Preparation and evaluation of rotigotine-loaded implant for the treatment of Parkinson’s disease and its evolution study

PURPOSE: To develop rotigotine-loaded implants (RI) to achieve continuous release of rotigotine for long duration for the treatment of Parkinson’s disease (PD). METHODS: RI was prepared by hot-melt extrusion method using poly (lactide-co-glycolide) (PLGA) as the matrix. In vitro drug release was opt...

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Detalles Bibliográficos
Autores principales:	Wang, Aiping, Liu, Yanxiang, Liang, Rongcai, Zhang, Xuemei, Sun, Kaoxiang, Wu, Zimei, Liu, Wanhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Pharmaceutical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881155/ https://www.ncbi.nlm.nih.gov/pubmed/27275128 http://dx.doi.org/10.1016/j.jsps.2016.04.022

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