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The Establishment of an Assay to Measure DNA Polymerase-Catalyzed Repair of UVB-Induced DNA Damage in Skin Cells and Screening of DNA Polymerase Enhancers from Medicinal Plants

An in vitro assay method was established to measure the activity of cellular DNA polymerases (Pols) in cultured normal human epidermal keratinocytes (NHEKs) by modifying Pol inhibitor activity. Ultraviolet (UV) irradiation enhanced the activity of Pols, especially DNA repair-related Pols, in the cel...

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Detalles Bibliográficos
Autores principales: Ikeoka, Sawako, Nakahara, Tatsuo, Iwahashi, Hiroyasu, Mizushina, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881493/
https://www.ncbi.nlm.nih.gov/pubmed/27153062
http://dx.doi.org/10.3390/ijms17050667