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Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia

Bone metastatic cells release bone microenvironment proteins, such as the matricellular protein SPARC (secreted protein acidic and rich in cysteine), and share a cell signaling typical of the bone metabolism controlled by Runx2. The megakaryocytes in the bone marrow engrafted by the metastases seem...

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Autores principales: Bendinelli, Paola, Maroni, Paola, Matteucci, Emanuela, Desiderio, Maria Alfonsina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881528/
https://www.ncbi.nlm.nih.gov/pubmed/27187355
http://dx.doi.org/10.3390/ijms17050706
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author Bendinelli, Paola
Maroni, Paola
Matteucci, Emanuela
Desiderio, Maria Alfonsina
author_facet Bendinelli, Paola
Maroni, Paola
Matteucci, Emanuela
Desiderio, Maria Alfonsina
author_sort Bendinelli, Paola
collection PubMed
description Bone metastatic cells release bone microenvironment proteins, such as the matricellular protein SPARC (secreted protein acidic and rich in cysteine), and share a cell signaling typical of the bone metabolism controlled by Runx2. The megakaryocytes in the bone marrow engrafted by the metastases seem to be one of the principal microenvironment sources of the biological stimuli, implicated in the formation of an osteoblastic niche, and affecting metastasis phenotype and colonization. Educated platelets in the circulation might derive from megakaryocytes in bone metastasis. The evaluation of predictive markers in the circulating platelets might be useful for the stratification of patients for therapeutic purposes. The hypoxic environment in bone metastasis is one of the key regulators of the network of the biological soluble and structural components of the matrix. In bone metastatic cells under hypoxia, similar patterns of Runx2 and SPARC are observed, both showing downregulation. Conversely, hypoxia induces Endothelin 1, which upregulates SPARC, and these biological stimuli may be considered prognostic markers of bone metastasis in breast carcinoma patients.
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spelling pubmed-48815282016-05-27 Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia Bendinelli, Paola Maroni, Paola Matteucci, Emanuela Desiderio, Maria Alfonsina Int J Mol Sci Review Bone metastatic cells release bone microenvironment proteins, such as the matricellular protein SPARC (secreted protein acidic and rich in cysteine), and share a cell signaling typical of the bone metabolism controlled by Runx2. The megakaryocytes in the bone marrow engrafted by the metastases seem to be one of the principal microenvironment sources of the biological stimuli, implicated in the formation of an osteoblastic niche, and affecting metastasis phenotype and colonization. Educated platelets in the circulation might derive from megakaryocytes in bone metastasis. The evaluation of predictive markers in the circulating platelets might be useful for the stratification of patients for therapeutic purposes. The hypoxic environment in bone metastasis is one of the key regulators of the network of the biological soluble and structural components of the matrix. In bone metastatic cells under hypoxia, similar patterns of Runx2 and SPARC are observed, both showing downregulation. Conversely, hypoxia induces Endothelin 1, which upregulates SPARC, and these biological stimuli may be considered prognostic markers of bone metastasis in breast carcinoma patients. MDPI 2016-05-11 /pmc/articles/PMC4881528/ /pubmed/27187355 http://dx.doi.org/10.3390/ijms17050706 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bendinelli, Paola
Maroni, Paola
Matteucci, Emanuela
Desiderio, Maria Alfonsina
Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia
title Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia
title_full Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia
title_fullStr Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia
title_full_unstemmed Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia
title_short Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia
title_sort cell and signal components of the microenvironment of bone metastasis are affected by hypoxia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881528/
https://www.ncbi.nlm.nih.gov/pubmed/27187355
http://dx.doi.org/10.3390/ijms17050706
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